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In this new comedy set on and beneath the streets of London, Roddy St. James (Hugh Jackman) is a pampered pet mouse who thinks heâ€™s got it made. But when a sewer rat named Sid (Shane Richie) â€“ the definition of â€œlow lifeâ€ -- comes spewing out of the sink and decides itâ€™s his turn to enjoy the lap of luxury, Roddy schemes to rid himself of the pest by luring him into the loo for a dip in the â€œwhirlpool.â€ Roddyâ€™s plan backfires when he inadvertently winds up being the one flushed away into the bustling world down below. Underground, Roddy discovers a vast metropolis, where he meets Rita (Kate Winslet), a street-wise rat who is on a mission of her own. If Roddy is going to get home, he and Rita will need to escape the clutches of the villainous Toad (Sir Ian McKellen), who royally despises all rodents and has dispatched two hapless henchrats, Spike (Andy Serkis) and Whitey (Bill Nighy), as well as his cousin -- that dreaded mercenary, Le Frog (Jean Reno) â€“ to see that Roddy and Rita are icedâ€¦ literally.