Grey's Anatomy - Isaiah Washington
Back in the earlier seasons of Grey's Anatomy, Cristina Yang and Preston Burke were the other big couple to watch on the ABC drama series. They had their ups and downs over the course of the three seasons of Isaiah Washington's run on the show, but the romance crumbled for good at the end of the third season. This came in the wake of some major backstage drama between Washington and Patrick Dempsey after actor T.R. Knight was reportedly late to set.

The details of the scuffle eventually became public and included reports that Washington used a homophobic slur in reference to T.R. Knight. Washington didn't do the best job of handling the situation afterward and even used (or repeated) the other-F-bomb when denying the reported incident to the press. Subsequently, his contract wasn't renewed after Season 3. Considering Burke was one of the key roles in the ensemble, as a close colleague to Derek and the love interest to Cristina, Washington's departure at the end of Season 3 felt abrupt, even with the widespread public reports of the backstage drama leading up to Burke's final appearance. The show went on without him, with various new doctors being introduced in seasons to follow, but it's hard not to wonder where things would have gone for Burke had Washington not left the series.

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