J.D. Vance (Gabriel Basso), a former Marine from southern Ohio and current Yale Law student, is on the verge of landing his dream job when a family crisis forces him to return to the home he’s tried to forget. J.D. must navigate the complex dynamics of his Appalachian family, including his volatile relationship with his mother Bev (Amy Adams), who’s struggling with addiction. Fueled by memories of his grandmother Mamaw (Glenn Close), the resilient and whip-smart woman who raised him, J.D. comes to embrace his family’s indelible imprint on his own personal journey.