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For Prototype 2's latest TV ad, Activision decided against using gameplay footage. Instead, they made a more emotional live-action ad set to the tune of Johnny Cash's "Hurt."
Prototype 2 takes place about a year after the events of the first game. A second outbreak of the Blacklight virus has led the military to quarantine Manhattan again. Sergent James Heller returns home to find that his family has been killed by the virus. He sets out to kill Alex Mercer, the protagonist of the first game who he believes is responsible.
When Mercer and Heller meet, Mercer easily defeats him. However, he doesn't kill him. Instead, Mercer infects Heller and grants him many of the same shape-shifting abilities that he has.
Prototype 2 will hit the PS3 and Xbox 360 in April. The PC version will follow in June.