Villainy has many forms, and villains keep coming up with new ways to invade our popular culture. Film baddies especially have a way of standing out -- with takes on real life menaces, as well as tailor-made baddies getting written for the big screen every year. But out of all of the antagonists with ill intentions this year, there are 10 that we've picked out as the most memorable. These worst-of-the-worst contenders would wish you a happy 2018, if they weren't busy trying to wreak havoc. So consider the following list a backhanded greeting for a pleasant new year.

10. Emily's Coma-inducing Disease (The Big Sick)

Let's start with an actual menace, courtesy of Kumail Nanjiani's The Big Sick. Throughout the film, we see the true story of how Kumail had to deal with his then recently ex-girlfriend, Emily, being hospitalized for a good portion of the film. Now on the more serious side, the complications that she suffered thanks to Still's Disease forced the doctors to put Emily in a medically-induced coma, as well as made her life difficult to live when she was first having problems. But in the less serious realm, this whole illness caused Kumail such heartache that he lost out on a spot at the Montreal Comedy Festival, thanks to bombing a stand-up routine with a heartfelt speech. Sure, it all worked out in the end, but it's a definite villain in a mostly charming movie.

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