John Stamos might be best known for his work on Full House, but the actor has had a lot of other work over the years. His most recent show, Grandfathered, might have been canceled, but like any show business vet would, he's quickly picked himself up and found a brand new gig. Stamos will be joining Season 2 of Scream Queens in the fall.

FOX confirmed to CinemaBlend today that John Stamos has signed up for the second season of Scream Queens. The show will take the scary mystery to a new setting in Season 2, with the action taking place in a hospital where some of the most exciting and extraordinary medical cases are being examined. Stamos will pay the hospital's secretive and brilliant head surgeon, Dr. Brock Holt. Scream Queens creator and executive producer Ryan Murphy worked with Stamos on two of his other shows, The New Normal and Glee.

John Stamos made his TV debut, and gained his first taste of fame, with his role as street kid Blackie Parrish on General Hospital in 1982. His two year stint on the soap opera led to other television work, but his acting career hit the big time when he landed the part of Jesse Katsopolis, better known as Uncle Jesse, on Full House. The comedy lasted from 1987 through 1995, and launched Stamos into instant name recognition status. After the show ended, he appeared in a string of TV movies, other shows and a few movies. His appearances include projects like The Larry Sanders Show, The Beach Boys: An American Family, Run Ronnie Run, Party Monster, Friends, Jake in Progress, ER and A Raisin in the Sun.

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FOX's Scream Queens was the number one new comedy for the 2015-2016 television season, and also the number one new series in social media. The horror/comedy/mystery focused on the ladies of Kappa Kappa Tau, a sorority at the fictional Wallace University, as they became the targets of a serial killer who uses the school's Red Devil mascot as a disguise. Season 1 regulars Jamie Lee Curtis, Emma Roberts, Lea Michele, Abigail Breslin, Keke Palmer, Glen Powell and Niecy Nash will be reprising their characters from the first season.

Season 2 of Scream Queens will likely continue the show's trend of blending a sincere mystery with blood and gore, brutal laughs, self-awareness and a lot of karmic justice for basically terrible people. The show managed to masterfully deliver some pretty drastic deaths and harrowing situations that still tickled the funny bone. Plus the humor was clearly on purpose, as opposed to some other horror series, where the laughs are usually completely unintentional (I'm looking at you, crazy ass American Horror Story).

I can't help but wonder if the hospital that will serve as the setting for this new season is going to be filled with as many nasty people as that university campus. Who am I kidding? Of course it will be. Sure, some decent or not-quite-deserving people will bite the scary dust, but I'm sure many a crap fest of humanity will be destined for the grave as well. We can all see what Season 2 of Scream Queens with John Stamos brings when the season debuts September 20, on FOX.

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