Even after 12 and a half seasons, Family Guy is still one of the most popular shows on TV. The comedy's continued success might have something to do with all the hilarious characters on the Animation Domination, sorry, Sunday Funday series--both regulars and guests alike. Here are ten of the most memorable guest stars to ever appear on Family Guy, at least so far.

10. Seth Rogen
It's probably not a coincidence that one of the best guest voices to appear on the animated comedy is one of Hollywood's funniest actor-writer-directors. Seth Rogen has actually been on Family Guy twice and, even though it was only for one line at a time, both cameos are extremely funny. And both happen in the seventh season. In "Family Gay," the eighth episode, he provides his voice for a 'Seth Rogen gene' injected into Peter before returning as himself in Episode 10, "FOX-y Lady," as a guest on Ellen. I probably shouldn't repeat what he says on the talk show here.

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