32 TV Shows That Lost Their Lead Character During Their Run

Characters come and characters go, at least that’s the case for these beloved shows. Whether it’s on one of the best sitcoms of all time, an exhilarating epic fantasy series, or crime dramas holding down a spot on the primetime lineup for decades, these programs all have one thing in common: they lost a fan-favorite before the final episode (or even final season).

Here are 32 TV shows that lost their lead character during their run…

The Office (2005 - 2013)

After being the best character on The Office for the show’s first seven seasons, Steve Carell’s Michael Scott left Dunder Mifflin’s Scranton office back in 2011. Though he would return in a guest capacity in the final season, the absence of the awkward, excitable, yet hilarious regional manager could be felt in the series’ final days.

That ‘70s Show (1998 - 2006)

That ‘70s Show had one of the best runs of any sitcom introduced in the final years of the 20th century, one that would carry on until May 2006. However, the sitcom’s main character, Topher Grace’s Eric Forman, wouldn’t be there for all of it. The actor, whose popularity was rising at the time, left the show after its seventh season. He would return in the series finale one year later.

Two And A Half Men (2003 - 2015)

Amid contract negotiations and a string of controversial incidents, Charlie Sheen left Two and a Half Men and stopped playing fan-favorite Charlie Harper, following the hit sitcom’s eighth season in 2011. One of the most popular shows on TV at the time, the CBS comedy would continue for four more seasons, with Ashton Kutcher coming on to play Walden Schmidt

Cheers (1982 - 1993)

A mainstay of Cheers for the show’s first five seasons, Shelley Long’s Diane Chambers left the friendly Boston bar for good when she was given the opportunity to become a professional writer. However, Diane would later return near the end of the show’s final season in 1993.

ER (1994 - 2009)

Whether it was Anthony Edwards’ Mark Greene being killed off in a spectacular way or George Clooney’s Doug Ross departing following a major scandal, ER lost several of its main characters throughout its 15-season (and 331-episode) run on NBC. However, the show always seemed to rebound from even the biggest losses.

Law & Order (1990 - Present)

Countless beloved characters have come and gone from Law & Order over the years, including NYPD detective Lennie Briscoe (Jerry Orbach), who was a mainstay of the legal drama for 12 years. The series is still on today (after being revived in 2022), but few of the detectives on the show have come close to touching the greatness of the wisecracking cop.

Three’s Company (1977 - 1984)

The late Suzanne Somers became a household name for her portrayal of Chrissy Snow on Three’s Company back in 1977. One of the three leads through much of the show’s run, Somers departed the series after its fifth season. The sitcom would run for three additional seasons after Somers left.

Scrubs (2001 - 2009)

Though Zach Braff’s Dr. John Michael “J.D.” Dorian was technically part of the Scrubs cast until the very last episode of Season 9 (he’s also returning for the upcoming reboot series), he only showed up in less than half of the final run. Maybe it was for the best, because those episodes were of a far lower quality than the previous eight seasons.

Bewitched (1964 - 1972)

This is an odd one simply because the Darrin Stephens character on Bewitched was written off, but instead recast near the end of the show’s run. Played by Dick York for the first few seasons, Elizabeth Montgomery’s on-screen husband was later played by Dick Sargent in the final years of the landmark sitcom about a witch trying to hide her true nature from the world around her.

Mom (2003 - 2021)

When the main star of a show leaves partway through the series run, it can be a nightmare for their co-stars and crew members, and that was the case when Anna Faris departed the hit CBS comedy Mom in 2020. Though the show continued for one more season after Christy Plunkett was written off, the absence of the former lead could be felt.

One Tree Hill (2003 - 2012)

One of the biggest shows of the 2000s, One Tree Hill was a perennial favorite of The WB (and later The CW) through much of its nine-season run. However, the good times didn’t last the whole time, as Chad Michael Murray, who played lead Lucas Scott, departed after season 6 alongside Hilarie Burton’s Peyton Sawyer.

Grey’s Anatomy (2005 - Present)

One of the longest-running shows in TV history, Grey’s Anatomy has always been known for its tremendous cast of characters. And while there are some, like Ellen Pompeo’s Meredith Grey, who have been there all along, others have come and gone. One of the biggest is Patrick Dempsey’s Derek Shepherd, aka "Dr. McDreamy," who was killed off in the show’s 11th season.

Glee (2009 - 2015)

In the middle of Glee’s successful run on Fox, the popular musical series lost one of its main characters when the actor who played him tragically died. In July 2013, Cory Monteith, who played Finn Hudson, died at the age of 31.

The Walking Dead (2010 - 2022)

So many characters came and went on The Walking Dead, which is to be expected considering it was a show set in the zombie apocalypse. However, one of the biggest departures came in the show’s ninth season when Andrew Lincoln’s Rick Grimes was written off the massively successful show.

House Of Cards (2013 - 2018)

House of Cards was a show with one shocking moment after another, including the time the Netflix series had to find a way to get rid of its main character before the sixth and final season. After Kevin Spacey found himself in legal trouble, the show’s producers decided to kill him off and carry on.

Blue’s Clues (1996 - 2006)

Steve Burns’ Steve was primarily the only human character on the hit Nick Jr. series, Blue’s Clues, for the show’s first four seasons. However, the actor left the animated show and was replaced by his character’s younger brother, Joe (Donovan Patton). Burns would later go on to appear in the Flaming Lips’ wild 2008 sci-fi film, Christmas on Mars.

The O.C. (2003 - 2007)

One of the main characters through the show’s first few seasons, Mischa Barton’s Marissa Cooper was killed off in heartbreaking fashion in The O.C.’s Season 3 finale. Following the departure of the tortured teenager, the show lasted one more season before coming to an end.

Charmed (1998 - 2006)

Prue Halliwell, played by the late Shannen Doherty, was one of the main characters in the first three seasons of Charmed. Though her fate was initially left up in the air following a Season 3 cliffhanger, it was later revealed that Prue died after her run-in with a powerful demonic assassin.

Laverne & Shirley (1976 - 1983)

One of the most popular spinoffs of all time (the characters originated on Happy Days), Laverne & Shirley ran for eight seasons on ABC between 1976 and 1983. However, while Penny Marshall’s Laverne DeFazio stayed around for the whole run, it was a different story for Cindy Williams’s Shirley Feeney. Williams, who was pregnant at the time, departed partway through what would ultimately be the final season.

Game Of Thrones (2011 - 2019)

Though Game of Thrones had numerous “main” characters over the course of its eight-year run, Sean Bean’s Ned Stark was one of the biggest in the first season. Creating one of the most shocking moments in TV history, Ned lost his head before the end of the first year, which set the tone for the unpredictable nature of the series moving forward.

The Vampire Diaries (2009 - 2017)

The Vampire Diaries was on the air for eight seasons between 2009 and 2017, but The CW’s popular book-to-screen adaptation lost its main character, Nina Dobrev’s Elena Gilbert, two-thirds of the way through. Though her character didn’t die, Debrov left for other opportunities.

Spin City (1996 - 2002)

The popular satirical comedy series, Spin City, ran on ABC for six seasons between 1996 and 2002, with most of those being led by Michael J. Fox as New York City deputy mayor Mike Flaherty. However, a couple of years after Fox was diagnosed with Parkinson’s disease, the actor left the series after its fourth season, with his character being written off by moving to Washington, D.C.

The Wire (2002 - 2008)

The Wire’s cast was full of incredible actors playing some of the best characters to ever grace the small screen. One of the major players in the landmark HBO series’ first three seasons was Idris Elba’s Stringer Bell, a ruthless and ambitious drug lord who aspired for more than running the corners in Baltimore. However, he made far too many enemies and he was brutally killed in the show’s Season 3 finale.

Oz (1997 - 2003)

Though Oz had a killer ensemble cast throughout the HBO series’ run between 1997 and 2003, it lost one of its lead players when Adewale Akinnuoye-Agbaje’s Simon Adebisi was killed off in the show’s fourth season. Imagine fans’ reactions the following year when he showed up in 2001’s The Mummy Returns.

Roseanne/The Conners (1988 - 2025)

Not long after Roseanne was brought back to TV in 2018, its star, Roseanne Barr, was fired in the fallout of a controversial tweet. The show was quickly cancelled and morphed into The Conners, which ran for seven seasons before coming to an end in 2025.

NCIS (2003 - Present)

A lot of people have left NCIS over the years, but the CBS crime drama continues to be one of the most popular shows on network TV. Perhaps the biggest character to come and go since the show’s 2003 debut is NCIS Supervisory Special Agent and Special Agent in Charge Leroy Gibbs, played by Mark Harmon, who stayed on through the 19th season. Talk about longevity.

8 Simple Rules For Dating My Teenage Daughter (2002 - 2005)

8 Simple Rules for Dating My Teenage Daughter, later shortened to 8 Simple Rules, had a nice little run on ABC back in the early 2000s, and even helped launch the career of Kaley Cuoco. The series was originally led by John Ritter, but his character, Paul Hennessy, was written off after the Three’s Company and Problem Child star suddenly died at the age of 54 while shooting the second season.

Lost (2004 - 2010)

Much like the show’s story, talking about main characters dying on Lost is a bit confusing, considering the non-linear structure of the long-running ABC drama series. Numerous characters like Shannon Rutherford (Maggie Grace), Michael Dawson (Harold Perrineau), and Charlie Pace (Dominic Monaghan) were written off and brought back later on in the series.

Homeland (2011 - 2020)

A once-great show that went on way too long, Homeland had its fair share of shocking moments and final episodes for major characters. At the top of that list is Nicholas Brody (Damian Lewis), a former prisoner of war whose true alliances are ambiguous through much of the show’s first three seasons. However, his time would come to an end a few years into the run when Brody was hanged in a public execution in Iran.

Boardwalk Empire (2010 - 2014)

Michael Pitt’s Jimmy Darmody was pretty much the 1B lead to Steve Buscemi’s Nucky Thompson in the first two seasons of Boardwalk Empire, but the up-and-coming gangster wouldn’t survive the 2011 season finale. The series would run for another three seasons before coming to an end in 2014.

Downton Abbey (2010 - 2015)

Dan Stevens’ Matthew Crawley was just one of multiple fan-favorite characters to be killed off during Downton Abbey during the show’s original run. The third-cousin, once removed of the Earl of Grantham, the character didn’t make it all that long in the grand scheme of things before dying in a car accident during the show’s third season.

Sons Of Anarchy (2008 - 2014)

Sons of Anarchy had an epic run on FX in the latter part of the 2000s through the early 2010s, and in that time, so many fan-favorites got killed off. The most horrifying came in the show’s fifth season when the beloved Opie (Ryan Hurst) was brutally murdered in prison. Some never came back after that.