John Stamos Seriously Went Off About Lori Loughlin’s Ex Mossimo Guinolli: ‘She Put Up With A Lot’

Lori Loughlin and John Stamos on Fuller House.
(Image credit: Netflix)

Earlier this month, it was announced that Full House alum Lori Loughlin was separating from Mossimo Guinolli, her husband of 28 years. The celebrity breakup comes five years after the couple served time in prison for their roles in the college admission scandal that got daughters Olivia Jade and Isabella Rose into USC under false pretenses. John Stamos apparently has some strong feelings about Guinolli, and he absolutely went off in defense of his former co-star.

John Stamos played Jesse Katsopolis on Full House several decades ago, with his character eventually marrying Lori Loughlin’s Rebecca Donaldson. The actors never took their romance off the screen, but just like most of the Full and Fuller House family, they’ve remained close friends. So when Stamos got to talking about Loughlin’s marriage coming to an end on the Good Guys podcast, he really didn’t hold back on how he thought his friend was better off. Stamos said:

I told her, I said, ‘Look, whatever negativity or hardships that you've been through in your life is connected to this guy.’

John Stamos was reportedly devastated about what happened to Lori Loughlin amidst her legal issues, as she was written off of Fuller House and fired by Hallmark, where she starred in When Calls the Heart. Stamos has defended her over the college admission scandal, saying she didn’t know what was going on.

He doubled down on that sentiment on the podcast, blaming Mossimo Guinolli — “She goes to fucking prison for this asshole.” — and saying she “didn’t deserve to be dragged through that.” When co-host Ben Soffer mentioned rumors of infidelity, John Stamos refused to confirm or deny but said:

I’m taking the fifth on that. Whatever he did to her, it busted her up to the core, and she put up with a lot over the years of this guy. And again, I'm not going to get into the relationship. It's not my business. I know a lot, and I was by her side through a lot of it. She is an angel, and she always made things better. She cleaned everything up.

Lori Loughlin’s actions following her release from prison in 2020 seem to back up John Stamos’ words, as she reportedly spent $500,000 — the same amount she and her husband were accused of illegally donating — to pay the full tuition and expenses for two other students to attend USC for four years.

As strong as the bond seems to be between the Uncle Jesse and Aunt Becky actors, there’s no love lost between John Stamos and Mossimo Guinolli, as the Grandfathered star continued:

He's a very successful dude, I will never talk to him again. He’s a terrible narcissist, and I don’t think you ever get out of that unless you’re able to. I know a little about his history, his family a little bit. I think when you have a wife like that and a family, how do you bust that up?

John Stamos thinks Mossimo Guinolli fumbled big time with Lori Loughlin, and the actor predicts Guinolli might come to regret some of his actions in the future. Stamos concluded:

Here’s what the honest to God truth [is], I pray for this guy. I pray that he gets a hold of whatever hole that he's trying to fill, however he's trying to fill it. I pray that he realizes that what he had was everything that anyone could ever hope for and that he gets some help. I think this guy needs help.

There’s certainly no mystery about what John Stamos thinks of his friend’s ex, and while we can’t be sure what Lori Loughlin thinks about his candidness, it’s probably nice to have people like Stamos who are willing to go so hard in the paint for you.

If you want to see John Stamos and Lori Loughlin share the screen, all eight seasons of Full House are available to stream with a Hulu subscription.

Heidi Venable
Content Producer

Heidi Venable is a Content Producer for CinemaBlend, a mom of two and a hard-core '90s kid. She started freelancing for CinemaBlend in 2020 and officially came on board in 2021. Her job entails writing news stories and TV reactions from some of her favorite prime-time shows like Grey's Anatomy and The Bachelor. She graduated from Louisiana Tech University with a degree in Journalism and worked in the newspaper industry for almost two decades in multiple roles including Sports Editor, Page Designer and Online Editor. Unprovoked, will quote Friends in any situation. Thrives on New Orleans Saints football, The West Wing and taco trucks.

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